The present work investigated some of these knowledge gaps through a controlled human study of the disposition of drugs in hair following oral methamphetamine administration. to smoked drugs), the lag time before a positive hair sample can be obtained after intake, and the role of melanin in drug incorporation, and correlations between dose and concentrations in hair are not yet fully understood. Cut-off concentrations and analytes to discriminate between drug use and passive exposure ( e.g. Nevertheless, many issues remain under discussion, including those of environmental contamination and removal of drugs due to different types of cosmetic treatments, and the ability of pre-analytical washing(s) of hair to remove external contamination and spare “actively” incorporated drug. Practically, hair testing offers significant advantages, as its collection and storage are simple and inexpensive, as compared to other body fluids. heroin use from morphine or codeine intake). Additional advantages are the possibility of segmental analysis to document drug use history over time, and the detection of parent compounds, often permitting discrimination between different sources of exposure (e.g. Advantages of hair testing as compared to analyses of other matrices for drugs is the much wider window of drug detection, enabling assessment of drug exposure well beyond the period of drug elimination from blood and urine. Hair analysis has gained a well established role in forensic and clinical testing for past exposure to drugs. Significant correlations were observed also between C max and melanin. A strong correlation was found between area under the curve of MAMP (r 2=0.90, p=0.00) and AMP (r 2=0.94, p=0.00) concentrations calculated for the 3-week period following administration and the total melanin concentration in hair. The percentage of MAMP and AMP removed with the washing procedure decreased with time after administration. The overall AMP/MAMP ratio ranged from 0.07 to 0.37 with a mean value of 0.15☐.07, and a median of 0.13. MAMP concentrations were above the 0.2 ng/mg cutoff for at least two weeks following administration of both low and high doses. Highly dose–related concentrations within subjects, but large variability between subjects were observed. AMP C max in hair was 0.1–0.3 ng/mg and 0.2–0.5 ng/mg, respectively, for low and high doses. MAMP T max occurred from 1 to 2 weeks after both doses, with C max ranging from 0.6–3.5 ng/mg after the low and 1.2–5.3 ng/mg after the high MAMP doses.
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